Heat and Exercise in Aging as Therapy (HEAT)
ConditionPrediabetic State
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50+
SponsorTexas Tech University
About this trial
The main goal of this two-phase clinical trial is to learn whether local heat therapy, using heat pads applied to the legs, can enhance skeletal muscle health, physical function, and blood sugar control in a manner comparable to exercise, specifically High-Intensity Interval Training (HIIT), in older individuals with prediabetes. The study aims to answer the following questions:
1. Does local heat therapy improve muscle architecture (e.g., muscle cross-sectional area, capillary density, mitochondrial content), glucose tolerance, and frailty indicators similarly to HIIT in older individuals with prediabetes? 2. Does local heat therapy as a pre-conditioning method enhance the skeletal muscle response to HIIT in older individuals with prediabetes?
Eligibility criteria
Qualifiers
Age ≥ 50 years
Women who are postmenopausal, defined as no menstrual period for at least 12 consecutive months.
Sedentary (structured exercise <30 minutes, 3x/week)
Body weight is at least 110 lbs
Disqualifiers
History of peripheral neuropathies
Currently taking prescription blood thinners
Medical complications that could would contraindicate participation in the high intensity interval training (HIIT) intervention including: orthopedic complications that would limit your ability to perform cycling exercise, significant cardiovascular impairments (e.g., history of arrhythmias, severe uncontrolled hypertension, etc.), diagnosed metabolic disease (e.g., diabetes), renal disease, sickle cell anemia, or cancer in remission for <6 months.
Known history of slow wound healing
Trial design
Treatments tested in this trial
- Heat therapy
- High-intensity interval training
Treatment groups
54 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov