Hemadsorption to Enhance Drug Elimination in Intoxications
ConditionIntoxication by Drug
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversitair Ziekenhuis Brussel
About this trial
In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired consciousness. This is a one arm interventional investigation where a hemadsorption filter is applied in patients fulfilling inclusion criteria 8 hours after admission. Plasma titer of the neurodepressing drug will be collected sequentially both before and after start of hemadsorption to evaluate the speed of drug elimination before and after application of a hemadsorption filter. Pre- and post filter titers will be obtained to evaluate adsorbability and to evaluate time to saturation of the filter.
Eligibility criteria
Qualifiers
older than18 years
Admission to ICU
GCS < 8 or requiring Flumazenil 8 hours after hospital admission
Having an intoxication with a benzodiazepine or tricyclic antidepressant that we can measure/quantify
Disqualifiers
Pregnant patient
Patients in chronic dialysis before admission
Need for mechanical ventilation for other reasons than intoxications (e.g. pneumonia, neurotrauma)
Concomitant pathology requiring continued intravenous sedation
Trial design
Treatments tested in this trial
- Hemadsorption filter
Treatment groups
18 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov