Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPeking Union Medical College Hospital
About this trial
This study prospectively observes changes in critical closing pressure (Pcc) and derived hemodynamic parameters in mechanically ventilated distributive shock patients when clinically indicated norepinephrine dose reduction is performed by the attending physician. Pcc is measured before and 30 minutes after dose reduction using a stepwise inspiratory hold maneuver via PiCCO monitoring.
Eligibility criteria
Qualifiers
Adult distributive shock patients aged ≥18 years;
Receiving norepinephrine infusion with MAP in the 75-85 mmHg range;
PiCCO catheter in situ;
Under mechanical ventilation;
Disqualifiers
Significant cardiac arrhythmia affecting CO measurement reliability;
Contraindication to airway plateau pressure maneuver;
Active titration of other vasoactive agents within 30 minutes prior to measurement;
Hemodynamic instability making it impossible to reduce norepinephrine dose.
Trial design
Treatments tested in this trial
- Not applicable- observational study
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov