Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMedical University of Graz

About this trial

Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.

Eligibility criteria

Qualifiers

Written consent of the participant after being informed

At least 18 years of age

End stage kidney disease patient undergoing hemodialysis

Dry weight stable for a minimum of one month

Disqualifiers

No informed consent was obtained

Patients with a pacemaker or implanted medical device that prevents compliance with study regulations

Patients treated with hemodiafiltration

Patients treated with medium cut-off membranes (Theranova, Baxter)

Trial design

Treatments tested in this trial

  • isolated Ultrafiltration (iso-UF)

Treatment groups

32 Participants
are divided into 2 treatment groups

Sponsors and collaborators