Hemoglobin Levels for Blood Transfusions During and After Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorOttawa Hospital Research Institute
About this trial
The goal of this pilot clinical trial is to learn if it is achievable to conduct a large-scale clinical trial whereby, the investigators will compare two ways of deciding when to give a blood transfusion during surgery. Participants in this study are adults undergoing surgery with a risk of significant blood loss.
The main question it aims to answer is:
* Is a trial designed to definitively test and compare two different red blood cell transfusion strategies feasible?
Participants will:
* Receive blood transfusions during surgery based on a higher (less than 90 g/L) or a lower (less than 70 g/L) hemoglobin value. * Complete questionnaires at 30 and 90 days after surgery.
Eligibility criteria
Qualifiers
Adult patients, age ≥18.
Elective or urgent surgery.
Risk of red blood cell transfusion of at least 10 percent.
Preoperative hemoglobin of less than 130 g/L.
Disqualifiers
Active major hemorrhage as indication for surgery (e.g. ruptured aneurysm, polytrauma, etc.).
Acute coronary syndrome or myocardial infarction within the past 6 weeks.
Cardiac surgery.
Liver transplantation.
Trial design
Treatments tested in this trial
- Restrictive Transfusion
- Liberal transfusion
Treatment groups
384 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov