The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement.
The primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy.
Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.
Age 18-75 years at the time of enrollment; signed informed consent
Clinical indication for HVPG measurement and/or transjugular liver biopsy for chronic advanced liver disease
Severe co-morbidities (e.g., advanced chronic heart failure, chronic renal insufficiency stage 4 and above, long-term poorly compensated diabetes mellitus with severe complications)
Pregnancy
Estimated patient non-compliance and/or not signing of the informed consent
Documented iodine contrast dye allergy
Military University Hospital, Prague
Lead sponsor
University Hospital Prague (IKEM), Prague, Czech Republic
Collaborator