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Hereditary Risk Factors for Thyroid Cancer

ConditionThyroid Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorDana-Farber Cancer Institute

About this trial

Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in children and families, with a particular interest in understanding genes and other factors that may put individuals at risk for developing thyroid cancer and thyroid nodules.

* In this study, family and medical history information is collected alongside a blood or saliva sample for genetic studies. * Individuals with a past or present childhood thyroid cancer/nodule or a thyroid cancer suspected to be inherited in their family are invited to participate.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s).

Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below).

Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (<18 years old).

Families with thyroid cancer in multiple individuals

Disqualifiers

Individuals who are unable to give informed consent.

Individuals who are unable to complete study materials.

Trial design

Design model

Single group

Treatments tested in this trial

  • •Referral to Genetic Counselor, if indicated

    Genetic

Treatment groups

250 Participants
are divided into 2 treatment groups
Group A: Lower Suspected Familial PredispositionNo intervention 0 interventions
Group B: Higher Suspected Familial PredispositionExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Number of participants who have childhood or suspected familial thyroid nodules/cancer

Time frame
2 years
2

Number of germline mutations identified associated with thyroid cancer predisposition

Time frame
2 years
3

Prevalence of suspected familial thyroid cancer among those with childhood thyroid nodules/cancer

Time frame
2 years

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Dana-Farber Cancer Institute

Lead sponsor

Source ClinicalTrials.gov
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