High Flow Nasal Oxygen for Exacerbation COPD
ConditionAcute Exacerbation of COPD
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorFranciscus Gasthuis
About this trial
In this pilot study the feasibility of performing a larger trial to study the non-inferiority of High Flow Nasal Oxygen compared to non-invasive ventilation in patients with acute acidotic hypercapnic exacerbation of COPD wil be investigated
Eligibility criteria
Qualifiers
Known chronic obstructive pulmonary disease
Acute hypercapnic exacerbation of this condition, defined as: PaCO2>45 mmHg or >6.0 kPa and pH 7.20-7.35
Age >40 years
Disqualifiers
Asthma
Immediate need for intubation, based on clinical judgement of the attending physician.
Impossibility to apply either one of the two interventions
Patient not expected to give immediate or delayed informed consent (e.g. known cognitive impairment, dementia, active serious psychiatric disease, mental retardation).
Trial design
Treatments tested in this trial
- HFNO
- NIV
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Franciscus Gasthuis
Lead sponsor
Reinier de Graaf Groep
Collaborator
Haga Medisch Centrum
Collaborator
Ikazia Hospital, Rotterdam
Collaborator
Source ClinicalTrials.gov