The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive Decline (SCD). Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).
Community dwelling men and women 65-89 years old
Ability to walk unassisted for 10 min
English speaking
No evidence of dementia or MCI based on cognitive screening (i.e., Montreal Cognitive Assessment (MoCA) score within normal limits for age, education, and sex using the NACC Uniform Data Set (UDS) norms8
If participants score less than 21 on the Telephone Interview for Cognitive Status (TICS)
Significant medical event requiring hospitalization in the past 6 months that has the potential to contaminate data being collected (fracture, hospitalization etc.)
Severe visual impairment or corrected visual acuity less than 20/40, which would preclude completion of assessments
Inability to undergo MRI brain imaging due to claustrophobia or implants such as pacemakers, heart valves, brain aneurysm clips, orthodontics, certain non-removable body jewelry, or shrapnel containing ferromagnetic metal
Parallel
Flicker Stimulation
BehavioralInvestigators will utilize near-infrared two-photon stimulation (890-940 nm) to deliver rhythmic input in a subliminal, comfortable manner, without the side effects associated with visible flicker.
Control Stimulation
BehavioralThe control group will receive a control stimulation rather than a constant flicker frequency.
18 Hz Visual Occlusion
BehavioralThe participants will wear visual occlusion glasses with visible stimulation flickering at 18 Hz
Control - Visual Occlusion
BehavioralParticipants will receive visible stimulation at a frequency that is 1 Hz.
Cognition
Investigators will comprehensively assess behavior at three times (baseline, half-way through (1.5 months), and after the intervention (3months)) using the TabCAT. Composite Scores will serve as primary metrics for cognition.
Grip strength
Participants will grip a machine which measures their grip strength in kg.
10m Gait Speed
Participants will walk unassisted for 10 meters. Their speed will be measured in seconds.
Clinical Test of Sensory Interaction on Balance (CTSIB)
Participants will, with eyes open and closed, walk on rough and smooth terrain. Investigators will measure sway area (measured in m\^2/s\^4).
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
