High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-89
SponsorUniversity of Florida

About this trial

The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive Decline (SCD). Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).

Eligibility criteria

Qualifiers

Community dwelling men and women 65-89 years old

Ability to walk unassisted for 10 min

English speaking

No evidence of dementia or MCI based on cognitive screening (i.e., Montreal Cognitive Assessment (MoCA) score within normal limits for age, education, and sex using the NACC Uniform Data Set (UDS) norms8

Disqualifiers

If participants score less than 21 on the Telephone Interview for Cognitive Status (TICS)

Significant medical event requiring hospitalization in the past 6 months that has the potential to contaminate data being collected (fracture, hospitalization etc.)

Severe visual impairment or corrected visual acuity less than 20/40, which would preclude completion of assessments

Inability to undergo MRI brain imaging due to claustrophobia or implants such as pacemakers, heart valves, brain aneurysm clips, orthodontics, certain non-removable body jewelry, or shrapnel containing ferromagnetic metal

Trial design

Treatments tested in this trial

  • Flicker Stimulation
  • Control Stimulation
  • 18 Hz Visual Occlusion
  • Control - Visual Occlusion

Treatment groups

60 Participants
are divided into 4 treatment groups

Sponsors and collaborators