About this trial
The goal is to determine whether three months of at least three times / week of sensory flicker stimulation improves cognition, mobility, and affect in healthy older adults and older adults with and without Subjective Cognitive Decline (SCD). Investigators will also determine whether the intervention slows cortical thinning and declines in brain functional network segregation and changes in blood biomarkers of Alzheimer's Disease (AD).
Eligibility criteria
Qualifiers
Community dwelling men and women 65-89 years old
Ability to walk unassisted for 10 min
English speaking
No evidence of dementia or MCI based on cognitive screening (i.e., Montreal Cognitive Assessment (MoCA) score within normal limits for age, education, and sex using the NACC Uniform Data Set (UDS) norms8
Disqualifiers
If participants score less than 21 on the Telephone Interview for Cognitive Status (TICS)
Significant medical event requiring hospitalization in the past 6 months that has the potential to contaminate data being collected (fracture, hospitalization etc.)
Severe visual impairment or corrected visual acuity less than 20/40, which would preclude completion of assessments
Inability to undergo MRI brain imaging due to claustrophobia or implants such as pacemakers, heart valves, brain aneurysm clips, orthodontics, certain non-removable body jewelry, or shrapnel containing ferromagnetic metal
Trial design
Treatments tested in this trial
- Flicker Stimulation
- Control Stimulation
- 18 Hz Visual Occlusion
- Control - Visual Occlusion