High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50+
SponsorUniversity of Alabama at Birmingham
About this trial
This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.
Eligibility criteria
Qualifiers
Age 50 years and older
Sedentary lifestyle, defined as < 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
Neurocognitive Impairment (as assessed using the BRACE+
Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
Disqualifiers
Diagnosis of mitochondrial disease
Active substance abuse or factors preventing compliance or safety
Uncontrolled hypertension, defined as resting BP > 150/90 mmHG
Chronic kidney disease
Trial design
Treatments tested in this trial
- High-Intensity Interval Training
- Continuous Moderate Exercise
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov