High-Risk prostatE Cancer radiatiOn Versus surgERy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age50-75
SponsorComprehensive Cancer Centre The Netherlands
About this trial
Prospective cohort study comparing robot-assisted radical prostatectomy and external beam radiotherapy +/- androgen deprivation therapy for high-risk non-metastatic prostate cancer in terms of health-related quality of life, functional outcomes, cost-effectiveness, progression-free survival and distant metastasis-free survival.
Eligibility criteria
Qualifiers
Histologically confirmed de novo non-metastatic high-risk prostate cancer.
cT3a-bN0M0, according to the 8th edition of the Tumour, Node, Metastasis (TNM) classification, with the exception that clinical T-stage will be based on digital rectal examination and magnetic resonance imaging (the highest stage will be used) and/or
International Society of Urological Pathology (ISUP) grade ≥4 and/or
Prostate-Specific Antigen (PSA) value at diagnosis greater than 20 ng/mL
Disqualifiers
Histological types other than adenocarcinoma
Diagnosis and/or treatment in a hospital abroad
Treatment with Androgen Receptor Targeted Agents (ARTA) as part of the initial treatment plan
Trial design
Treatments tested in this trial
- Not listed
Trial groups
837 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov