About this trial
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.
Eligibility criteria
Qualifiers
Age: 19 - 39.
Willing to visit the lab on 3 separate occasions.
Disqualifiers
Previously diagnosed heart condition,
Previously diagnosed lung condition (including asthma),
Previously diagnosed metabolic condition,
Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,
Trial design
Treatments tested in this trial
- Diphenhydramine hydrochloride
- Placebo
- Exercise Bout