Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorThe University of Texas Health Science Center, Houston

About this trial

The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms

Eligibility criteria

Qualifiers

confirmed HD mutation carriers and/or established family history alongside typical symptoms (i.e. chorea) of HD;

early (stages 1 and 2) or moderate (stage 3) stages according to Shoulson-Fahn

exhibit mild to moderate behavioral symptoms defined by severity scores in the PBA-S between 1 and 3 for any of the evaluated symptoms and no symptoms with a severity score of 4

stable doses of medications for at least one month

Disqualifiers

unstable medical conditions

history of epilepsy

metallic objects in the brain

Have a caregiver willing to be present during tDCS sessions and answer questionnaires.

Trial design

Treatments tested in this trial

  • active tDCS

Treatment groups

10 Participants
are divided into 1 treatment group