About this trial
Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes.
Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.
Eligibility criteria
Qualifiers
Adult (≥18years old at the time of giving consent)
Consented and listed for bilateral tonsillectomy or adenotonsillectomy
Tonsillectomy performed within the trial study period
Disqualifiers
Any concurrent Head & Neck (H&N) malignancy
Unilateral tonsillectomy
Pregnancy
Concurrent pharyngeal or upper aerodigestive tract biopsy
Trial design
Treatments tested in this trial
- Manuka honey MGO 1000
- Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring
Treatment groups
Sponsors and collaborators
East and North Hertfordshire NHS Trust
Lead sponsor
Manuka Doctor UK Ltd
Collaborator
National Institute for Health Research, United Kingdom
Collaborator