HONEY for the Treatment of POst-Tonsillectomy Pain

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorEast and North Hertfordshire NHS Trust

About this trial

Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes.

Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.

Eligibility criteria

Qualifiers

Adult (≥18years old at the time of giving consent)

Consented and listed for bilateral tonsillectomy or adenotonsillectomy

Tonsillectomy performed within the trial study period

Disqualifiers

Any concurrent Head & Neck (H&N) malignancy

Unilateral tonsillectomy

Pregnancy

Concurrent pharyngeal or upper aerodigestive tract biopsy

Trial design

Treatments tested in this trial

  • Manuka honey MGO 1000
  • Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring

Treatment groups

100 Participants
are divided into 2 treatment groups

Sponsors and collaborators

East and North Hertfordshire NHS Trust

Lead sponsor

Manuka Doctor UK Ltd

Collaborator

National Institute for Health Research, United Kingdom

Collaborator