How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Pittsburgh

About this trial

The goal of this clinical trial is to learn how different protein types affect the body's metabolism and immune system in healthy adults. The main questions it aims to answer are:

Does drinking smoothies with animal-based or plant-based protein change the level of amino acids like leucine in the blood?

Does adding leucine to a plant-based smoothie make the body respond like it does to an animal-based smoothie?

Participants will:

Come to the research clinic for 3 study visits

Drink a high-protein smoothie at each visit (one with animal protein, one with plant protein, and one with plant protein + leucine)

Give blood samples before and 1 and 3 hours after each smoothie

Researchers will look at how the body's metabolism and immune system respond. They are especially interested in a pathway called mTOR, which helps control how cells use nutrients and may be involved in heart disease like atherosclerosis.

All smoothies are prepared to meet Halal and Kosher dietary guidelines.

Eligibility criteria

Qualifiers

Age 18-65 years

BMI 18.5-29.9 kg/m²

Generally healthy, without known chronic illness and/or treatment with chronic medications

Willing to comply with dietary restrictions and study procedures

Disqualifiers

History of cardiovascular disease, diabetes, or autoimmune disorders

Active use of anti-inflammatory, immunomodulatory, or lipid-lowering medications

Renal or hepatic dysfunction

Pregnancy or breastfeeding

Trial design

Treatments tested in this trial

  • Animal-Based Protein Smoothie
  • Plant-Based Protein Smoothie
  • Plant-Based Protein Smoothie with Leucine

Treatment groups

20 Participants
are divided into 3 treatment groups

Sponsors and collaborators