How do Patients With Amnesia Acquire New Knowledge?

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity Hospital, Toulouse

About this trial

THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.

Eligibility criteria

Qualifiers

Patients aged between 18 and 70 years

Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation

Written agreement to participate in the study

Intellectual capacities compatible with the cognitive tasks and signing of consent

Disqualifiers

Subjects under the age of 18 or over 70

Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)

Refusal to be informed of an anomaly detected during the MRI

Trial design

Treatments tested in this trial

  • MRI
  • Psychometric

Treatment groups

150 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University Hospital, Toulouse

Lead sponsor

National Research Agency, France

Collaborator