How Metabolism Affects Weight Loss and Gain
ConditionObesity and Overweight
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorUniversity Hospital Schleswig-Holstein
About this trial
This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight. The investigators will measure how the human body uses energy during a fasting period and after consumption of a specially designed, low-protein meal. By comparing these responses, the investigators aim to identify different "metabolic phenotypes" that affect weight control. Findings from this research may lead to more personalized treatments for managing weight. Participation in this study involves simple tests and basic body measurements.
Eligibility criteria
Qualifiers
Group 1 (Lean): BMI 18.5-22.0 kg/m², reporting difficulty gaining weight
Group 2 (Obese): BMI >30 kg/m², reporting difficulty losing weight
Healthy status as determined by medical history, physical examination, and laboratory tests
Stable weight (less than 5% fluctuation) over the past 6 months
Disqualifiers
Prediabetes (HbA1c >5.6% or fasting blood glucose >100 mg/dL) or diabetes mellitus
Conditions affecting appetite or energy expenditure (e.g., Cushing's syndrome, uncontrolled hyper-/hypothyroidism)
Gastrointestinal disorders that impact nutrient absorption (e.g., inflammatory bowel disease, malabsorption syndromes, ulcers)
Psychiatric conditions influencing eating behavior (e.g., active depression, anorexia nervosa, bulimia nervosa, borderline personality disorder)
Trial design
Treatments tested in this trial
- Not listed
Trial groups
20 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov