HPV Screening With Triage by HPV Genotyping Versus Visual Inspection With Acetic Acid

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age25-49
SponsorProf. Patrick Petignat

About this trial

Cervical cancer is the leading cause of cancer death among women in sub-Saharan Africa, despite the existence of effective prevention and screening methods. Because vaccination rates against human papillomavirus (causing nearly all cervical cancers) are still insufficient in some low-resource countries, early detection and treatment of cervical lesions at risk of progressing to cancer are crucial components of cervical cancer control. Therefore, it is essential to find the most reliable and appropriate screening strategy in the context of low-resource countries in order to identify women in need of treatment and thus prevent the development of cervical cancer. The objective of our study is to compare two different methods of cervical cancer screening adapted to low-resource settings, in two study centers in Cameroon.

Eligibility criteria

Qualifiers

HIV-negative women aged 30-49 and HIV-positive women aged 25-49 years old

Ability to understand study procedures and accepting voluntarily to participate by signing an informed consent form (ICF).

Disqualifiers

Pregnancy at the time of screening

Previous hysterectomy

Known cervical cancer

Symptoms of cervical cancer (e.g. metrorrhagia, known pelvic mass)

Trial design

Treatments tested in this trial

  • HPV genotyping
  • Visual inspection after application of acetic acid

Treatment groups

5,500 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Prof. Patrick Petignat

Lead sponsor

University Hospital, Geneva

Sponsor institution

University Hospital, Geneva

Collaborator

Bafoussam Regional Hospital, Cameroon

Collaborator

Dschang District Hospital, Cameroon

Collaborator

University of Dschang

Collaborator