Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorQueen's University
About this trial
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are:
How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest?
Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest:
* Magnetic resonance imaging of the thigh muscles * Strength testing of the thigh muscles * Insulin sensitivity testing in response to a mixed meal * Exogenous glucose oxidation in response to a mixed meal * Muscle biopsies from the thigh muscles * Blood samples
Eligibility criteria
Qualifiers
Males and females 18-30 years
BMI between 18.5-28 kg/m2
Weight stable (within ±2kg for 6 months)
Generally healthy as assessed by medical and physical activity questionnaires
Disqualifiers
a BMI < 18.5 and > 28 kg/m2
the use of insulin to control blood glucose levels
a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases
the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)
Trial design
Treatments tested in this trial
- Bedrest
Treatment groups
12 Participants
are divided into 1 treatment groupSponsors and collaborators
Queen's University
Lead sponsor
Kingston Health Sciences Centre
Sponsor institution
Canadian Institutes of Health Research (CIHR)
Collaborator
Source ClinicalTrials.gov