Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-75
SponsorBeijing Chao Yang Hospital

About this trial

1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2. The main questions it aims to answer is:

Whether HBO can improve the prognosis of ischemic stroke patients after endovascular treatment? 3. Participants will:

receive HBO (1.6 Atmosphere Absolute,1.6ATA),Once a day, for 1 hour each time, for 5 days a week (it can be non-consecutive days), the total course of treatment is 10 times.

undergo three scheduled face to face or telephone follow-up assessments during the 12-month period following HBO.

Eligibility criteria

Qualifiers

35-75 years

The symptoms and signs are consistent with acute anterior circulation ischemic stroke. The immediate postoperative angiographic recanalization grade was ≥ 2b.

Neurological deficit score at the time of enrollment: 5 ≤ NIHSS ≤ 15 points

Consciousness status (NIHSS 1a-1b items): 0-1 point

Disqualifiers

Subjects with HBO contraindications or intolerance

Postprocedural imaging identified either procedure-related subarachnoid hemorrhage or hemorrhagic transformation

Based on the medical history, it is suspected that the cerebral embolism is caused by sepsis or infective endocarditis

Expected lifespan < 90 days

Trial design

Treatments tested in this trial

  • Hyperbaric Oxygen Therapy
  • Conventional therapy group

Treatment groups

424 Participants
are divided into 2 treatment groups

Sponsors and collaborators