Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12-17
SponsorKing's College London
About this trial
The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is:
What is the prevalence of hypertension in a population sample of adolescents with ADPKD?
Participants will have the following measurements performed:
* Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.
Eligibility criteria
Qualifiers
Age 12 - 17 years at the time of consent
Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test)
Parent with confirmed clinical diagnosis of ADPKD
Parent (if child <16 years) or both parent and young person (if >=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this.
Disqualifiers
18 years or above at the time of study entry
Unable to tolerate key study investigations
Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations
Unwilling to undergo genetic testing for ADPKD
Trial design
Treatments tested in this trial
- Not listed
Trial groups
200 Participants
are grouped into 2 trial groupsSponsors and collaborators
King's College London
Lead sponsor
Guy's and St Thomas' NHS Foundation Trust
Collaborator
Source ClinicalTrials.gov