The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia after extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest.
OHCA
Age of 18-75 years, known or estimated
An initial cardiac arrest rhythm of ventricular fibrillation/pulseless ventricular tachycardia or pulseless electrical activity
ECMO initiated after sustained return of spontaneous circulation (ROSC) and patients with sustained ROSC before ECMO initiation
OHCA of presumed non-cardiac etiology
Time from emergency call or witnessed arrest to hospital arrival of >60 min
Time from hospital arrival to ECMO initiation of >60 min