The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.
Age ≥18 years.
A clinical plan for invasive coronary angiography.
Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
Able to comply with study procedures.
A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
History of coronary artery bypass surgery.
Presence of obstructive disease evident in a main coronary artery (diameter >2.5 mm), i.e. a coronary stenosis >50% and/or a fractional flow reserve (FFR) ≤0.80*.
Logistical reason*. *These patients will enter a follow-up registry.
NHS Greater Glasgow and Clyde
Lead sponsor
University of Glasgow
Collaborator
Abbott Medical Devices
Collaborator