To find out whether it is possible to run a study looking at the underlying markers of ageing in muscle quality and quantity in men receiving Androgen Deprivation Therapy for prostate cancer treatment.
To determine the feasibility of conducting an observational study examining the association of fundamental biological markers of ageing with changes in body composition and skeletal muscle morphology following ADT in older men undergoing prostate cancer treatment.
Age ≥65 years old at time of recruitment
Able to provide informed consent to participate
Known prostate cancer due to be initiated on ADT for the first time (with or without Androgen Receptor Targeted Agents (ARTA) or radiotherapy), or initiated within two weeks prior to recruitment.
Individuals involved in other research will be eligible to participate so long as the other research does not involve potential changes to the standard ADT care the participant will be receiving and does not involve an intervention aimed at reducing the muscle atrophy associated with ADT.
Systemic anti-cancer therapy within one year of recruitment (for prostate cancer or any other concomitant cancer)
Planned surgery (not including eye surgery or other minor surgery) within six months of ADT
Any other condition previous or current which, in the judgement of the responsible clinician, is likely to interfere with the trial / assessments.
Lacks capacity to consent
Guy's and St Thomas' NHS Foundation Trust
Lead sponsor
King's College London
Collaborator