Identifying Genetic Targets in Gynecological Tumors
ConditionOvarian Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18+
SponsorAzienda USL Reggio Emilia - IRCCS
About this trial
This observational study aims to identfy genetic targets involved in the pathogenesis of gynecological tumors, with a focus on high-grade serous ovarian carcinoma. Using a triple approach - in silico, ex vivo and in vitro - the study will investigate the role of gonadotropins and their related signaling pathways in the epithelial ovarian cancers. Gene and protein expression levels will be evaluated through transcriptomic analysis, immunohistochemistry and functional assays on tumor cell lines. The goal is to uncover potential diagnostic or therapeutic targets in gynecological malignancies.
Eligibility criteria
Qualifiers
Adult women ≥18 years old
Histologically confirmed diagnosis of epithelial ovarian cancer (including high- grade serous, endometrioid, mucinous, clear cell, or mesonephric-like histotypes)
Signed informed consent (for prospective cases) or ethically approved waiver (for retrospective samples)
Disqualifiers
Refusal to sign informed consent
Diagnosis of low-grade or non-epithelial ovarian tumors
Patients whose clinical or pathological data are unavailable or insufficient for study inclusion
Trial design
Treatments tested in this trial
- RNA extraction and gene expression
Treatment groups
180 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov