IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorLucas R. Cusumano, MD
About this trial
Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual patients. Changes in metabolic activity on non-invasive imaging may correlate with improvement in symptoms of knee osteoarthritis. This study will assess changes in metabolic uptake on a hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) system in subjects undergoing GAE.
Eligibility criteria
Qualifiers
Provided informed consent
Age ≥ 40 years
Ineligibility for or refusal of surgical management
Moderate-severe knee pain as determined by visual analog scale > 5 out of 10
Disqualifiers
Mild knee pain as determined by visual analog scale < 5 out of 10
OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation
Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL/min.
Significant arterial atherosclerosis that would limit selective angiography
Trial design
Treatments tested in this trial
- Embolization
Treatment groups
25 Participants
are divided into 1 treatment groupSponsors and collaborators
Lucas R. Cusumano, MD
Lead sponsor
University of California, Los Angeles
Sponsor institution
Source ClinicalTrials.gov