Imaging Histone Deacetylase in the Heart

ConditionsHeart Failure With Normal Ejection Fraction Left Ventricular Hypertrophy Aortic Valve Stenosis Diabetes

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-85

SponsorMassachusetts General Hospital

About this trial

The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.

Eligibility criteria

Qualifiers

Healthy adults with no known history of medical disease

Age 18-85 years

No history cardiovascular disease

Ability to provide informed consent

Disqualifiers

Known contraindication to MRI

Trial design

Treatments tested in this trial

11C-Martinostat
PET-MRI

Treatment groups

96 Participants

are divided into 3 treatment groups

Sponsors and collaborators

Massachusetts General Hospital

Lead sponsor

Source ClinicalTrials.gov