Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversity Hospital Tuebingen

About this trial

Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression.

Main tasks are:

* Analysis of CO2-triggered BOLD fMRI for analysis of cerebral hemodynamics in comparison to H2 15O PET/CT * Analysis of longitudinal changes of contrast enhancement in vessel-wall imaging and correlation of disease activity with biosampling * Definition of a standardized recommendation for pre- and postoperative imaging of Moyamoya patients

Eligibility criteria

Qualifiers

Patients with suspicion of Moyamoya Disease

Patients able to understand the study and to give their informed consent

Disqualifiers

Cerebral vascular disease caused by atherosclerosis

Vasculitis

Contraindications to MRI

Contraindications to PET/CT

Trial design

Treatments tested in this trial

  • MRI
  • H2 15O PET/CT
  • Biosampling

Treatment groups

50 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University Hospital Tuebingen

Lead sponsor

University Hospital Freiburg

Collaborator