Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Pittsburgh
About this trial
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Eligibility criteria
Qualifiers
Age 18-49
Right-handed
Native English speaker
Age 18 or older
Disqualifiers
Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
Trial design
Treatments tested in this trial
- Neural responses to speech functional localizer
- Neural responses to silent articulation
- Neural responses to self vs. externally generated speech
- Event-related potentials for speech
- Neural responses to induced speech errors
- Neural responses to sensory-motor adaptation
- Speech production behaviors
- Auditory acuity testing
- Neural responses to learning a non-speech auditory motor behavior
Treatment groups
100 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Pittsburgh
Lead sponsor
Northwestern University
Collaborator
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator
Source ClinicalTrials.gov