The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will address our goal by using neuroimaging and blood plasma biomarkers, as well as molecular pathology.
Age 18 years or older
Meet possible or probable CBS criteria
Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)
Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome
Subjects will be excluded if they have a mutation in the progranulin gene
Subjects will excluded if they have received anti-Aβ therapy
Jennifer Whitwell
Lead sponsor
Mayo Clinic
Sponsor institution
National Institute on Aging (NIA)
Collaborator