A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial that aims to evaluate the effect of immediate angioplasty (with or without stenting) for acute ischemic stroke (AIS) with severe intracranial atherosclerotic stenosis (ICAS) in improving the 90-day functional outcome.
Aged 18 years or older.
Diagnosed with AIS and baseline NIHSS ≥6.
Pre-stroke mRS ≤2.
Time from symptom onset to randomization ≤ 24 hours; the onset time refers to "Last Known Well" (LKW).
Normal diameter of the culprit vessel <2.0 mm.
Isolated perforator artery infarction (except for combined cortical hypoperfusion).
Hemorrhagic stroke within the past 90 days.
Cerebrovascular conditions such as vasculitis, moya-moya disease, arterial inflammatory stenosis, vasospasm, traumatic dissection, etc..
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lead sponsor
Shenzhen Hospital of Southern Medical University
Collaborator