Prospective, biological, observational study involving the collection and use of samples from patients suffering from NSCLC lung cancer, aimed at comparing the molecular profile related to metabolism among subjects with response or resistance to checkpoint inhibitors immune system (ICI), in order to contribute to define response biomarkers and new molecular pathways as therapeutic targets combine with ICI to overcome resistance.
Age > 18 years
Histological diagnosis of advanced stage NSCLC
Histotype adenocarcinoma and squamous carcinoma
ECOG PS <2
Contraindications to immunotherapy
Unavailability of tumor tissue
Histotype with neuroendocrine or mixed component
Contraindication to immunotherapy
Regina Elena Cancer Institute
Lead sponsor
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Collaborator