Immune Responses in Health Care Personnel
ConditionInfluenza
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-64
SponsorFinnish Institute for Health and Welfare
About this trial
This is an investigator-initiated 10 year long open cohort observational study, aiming to increase the understanding of the humoral and cellular immunological mechanisms of vaccination against influenza, including effects of repeated vaccination, the duration of protection, immunity against circulating viruses, as well as factors affecting the immunological responses and immunity against other vaccine preventable infectious diseases among health care personnel.
Eligibility criteria
Qualifiers
Members of health care or laboratory personnel in HUS having decided to take the seasonal influenza vaccination by the routine occupational health care service
General good health as established by or volunteer's own statement
Written informed consent
Presumably able and willing to participate in the study during the starting influenza season
Disqualifiers
Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
Administration (longer than 14 days) of immunosuppressants or other immune- modifying drugs within 6 months before the vaccination; oral corticosteroids in dosages of 20 mg/day or more prednisolone or equivalent are excluded; inhaled or topical steroids are allowed.
Pregnancy or lactation
Acute disease at the time of enrolment (defined as the presence of a moderate or severe illness with or without fever)
Trial design
Treatments tested in this trial
- influenza vaccine
Treatment groups
150 Participants
are divided into 1 treatment groupSponsors and collaborators
Finnish Institute for Health and Welfare
Lead sponsor
Hospital District of Helsinki and Uusimaa
Collaborator
Source ClinicalTrials.gov