The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowledged threshold, in a well conducted antibiotherapy context, in patient admitted in the Intensive Care Unit.
The main questions it aims to answer are:
* evaluation of the association between death and persistence of immunoplegia using HLA-DR monitoring * search an association between immunoplegia depth and severity of the initial state of shock * search an association between immunoplegia depth and viral reactivation * compare association of immunoplegia duration and HLA-DR nadir and VAP occurrence Blood samples will be taken from participants to HLA-DR dosage, at the time of inclusion and once a week then.
Patient over 18 years old
Patient admitted in the Intensive Care Unit of the CHIAP
Patient under mechanical ventilation
Patient with infectious pneumonia
Patient under 18 years old
Patient with severe neutropenia (neutrophils < 0.5 G/L)
Patient under immunosuppressive treatment
Use of corticosteroids (intravenous or oral) prior to ICU admission