Immunomodulation During Pregnancy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18+
SponsorUnidade Local de Saúde de Coimbra, EPE
About this trial
The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells, Th cells).
Participants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.
Eligibility criteria
Qualifiers
Singleton pregnancy
Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation
Gestational age determined by first-trimester ultrasound
Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm. LDA-naïve.
Disqualifiers
Autoimmune diseases
Prior use of LDA or other immunomodulatory medication before potential recruitment
History of spontaneous miscarriages and/or medical termination of pregnancy
Fetal malformation
Trial design
Treatments tested in this trial
- Not listed
Trial groups
30 Participants
are grouped into 1 trial groupSponsors and collaborators
Source ClinicalTrials.gov