Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorUniversity of Roma La Sapienza

About this trial

The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS). Investigators hypothesize that adrenalectomy in selected patients, following the 2016 European Congress of Endocrinology (ECE) guidelines, can improve metabolic parameters and cardiovascular risks and features.

Eligibility criteria

Qualifiers

Incidentally detected adrenal mass

Disqualifiers

Patients with overt Cushing's syndrome, pheochromocytoma, Conn syndrome, adrenocortical carcinoma, late-onset congenital adrenal hyperplasia, adrenal metastasis and adrenal hemorrhage

Patients taking medications influencing glucocorticoid production or metabolism

Patients with psychiatric diseases or alcohol abuse

Pregnancy

Trial design

Treatments tested in this trial

  • Adrenalectomy

Treatment groups

68 Participants
are divided into 4 treatment groups

Sponsors and collaborators