Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorRijnstate Hospital

About this trial

Hypertension is a major risk factor for a variety of cardiovascular diseases. When hypertension results from increased vascular resistance due to a narrowing of the descending aorta, it can be effectively treated with stenting. More recently, evidence suggest that stenting in more distal parts of the arterial vascular bed is also associated with a reduction in blood pressure. The investigators hypothesize that stenting of occlusions more distal of the descending aorta decreases the central blood pressure and afterload as reflected by NT-proBNP (N-terminal pro-Brain Natriuretic Peptide), a biomarker of intracardiac pressures and predictor of heart failure events. The goal of this pilot study is to prospectively investigate changes in blood pressure after stent placement in the aorto-iliac region.

Eligibility criteria

Qualifiers

Age ≥18 years

Singed informed consent

Chronic occlusion in the infrarenal aorta and/or one or both common iliac arteries

Total lesion length of ≥30mm

Disqualifiers

Patient is unable to understand the study requirements and/ or is unwilling to adhere to the follow-up

Juxtarenal pathology (<2cm below the lowest renal artery)

Acute occlusion of the target area (Acute Leriche Syndrome)

Embolic disease

Trial design

Treatments tested in this trial

  • Stent placement

Treatment groups

20 Participants
are divided into 1 treatment group

Sponsors and collaborators