Impact of Cocaine Use and Withdrawal on Sleep
ConditionCocaine Use Disorder
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHôpital le Vinatier
About this trial
This study investigates how cocaine use and withdrawal affect sleep and circadian rhythms in individuals undergoing inpatient detoxification. Using wearable sleep monitors, actigraphy, questionnaires, and hormonal biomarkers, it aims to capture both objective and subjective changes in sleep across three key stages: active use, early withdrawal, and late withdrawal. The study is unique in its ability to explore sleep microstructure, the circadian system's role via melatonin and cortisol measurements, and the dynamic relationship between subjective sleep perception and objective sleep data. It also examines whether sleep quality may serve as a predictive marker of long-term withdrawal success.
Eligibility criteria
Qualifiers
Male or female, aged 18 years or older
Meeting DSM-5 criteria for cocaine use disorder
Positive urine drug screen for cocaine
Scheduled for inpatient supervised cocaine detoxification within the next four weeks
Disqualifiers
Current diagnosis of opioid use disorder or other psychostimulant use disorders (e.g., amphetamines, methamphetamines, cathinones, methylphenidate)
Unstable psychiatric disorder or somatic illness deemed incompatible with study participation by the investigator
Current treatment with methylphenidate, modafinil, solriamfetol, melatonin, pitolisant, naltrexone, or bupropion
Patients under legal guardianship
Trial design
Treatments tested in this trial
- Multimodal Sleep and Biomarker Assessment
Treatment groups
32 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov