Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-90
SponsorWest China Hospital
About this trial
Advanced age is a consistent risk factor for the incidence of postoperative cognitive decline, which is associated with longer hospital stays, decreased quality of life, and increased mortality. Anaesthetic drugs can also affect postoperative cognition, as their residual effects can alter central nervous system activity. Desflurane and sevoflurane are widely used volatile anesthetics. Choice anesthetics may influence the occurrence of postoperative delirium. However, evidence in this aspect is conflicting.
Eligibility criteria
Qualifiers
Age ≥ 65 years and < 90 years;
Scheduled to undergo non-cardiac or non-neurosurgery with an expected duration of 2 hours or more, under general anesthesia;
Agree to participate, and give signed written informed consent.
Disqualifiers
Preoperative history of schizophrenia, epilepsy, parkinsonism or any diseases of central nervous system;
Inability to communicate in the preoperative period (coma, dementia, language barrier, impaired hearing or vision);
Severe diseases in cardiovascular, respiratory, liver, kidney, or preoperative American Society of Anesthesiologists physical status classification ≥ IV;
Alcoholism and drug dependence;
Trial design
Treatments tested in this trial
- Desflurane
- Sevoflurane
Treatment groups
890 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov