Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50+
SponsorBispebjerg Hospital
About this trial
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function.
Hypotheses:
The first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body.
The second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.
Eligibility criteria
Qualifiers
Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) < 2.5 or hyperemic myocar-dial blood flow (hMBF)<2.3 ml/g/min using [15O]H2O-PET
No obstructive coronary artery disease
Disqualifiers
Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile
Heart failure, defined as left ventricular ejection fraction of less than 40%
Uncontrolled hypertension defined as blood pressure above target 140/90 for all
Co-morbidity resulting in <1 year expected survival
Trial design
Treatments tested in this trial
- Exercise training
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Bispebjerg Hospital
Lead sponsor
University of Copenhagen
Collaborator
Source ClinicalTrials.gov