Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorShanghai General Hospital, Shanghai Jiao Tong University School of Medicine
About this trial
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on:
1. Comparing the gut microbiota composition between kidney stone patients and healthy controls, with emphasis on analyzing the relative abundance of Lactobacillus salivarius 2. Comparing the differences in tryptophan metabolite levels such as indole-3-carboxylic acid (ICA) and kynurenine (Kyn) in serum between the two groups 3. Exploring the correlation between gut microbiota composition and tryptophan metabolite levels 4. Analyzing the influence of different environmental conditions (seasons, temperature and humidity) on gut microbiota and metabolite levels
Eligibility criteria
Qualifiers
Inclusion criteria for patients with kidney stones
Age>=18 years;
Diagnosed with kidney stones by ultrasound, CT or urography;
Willing to provide stool samples and serum samples for study;
Disqualifiers
Use of antimicrobials or probiotics within the past 3 months;
Presence of active urinary tract infection;
Presence of other serious systemic diseases, such as hepatic or renal insufficiency, cardiac or pulmonary diseases, malignant tumors, and immunodeficiency states;
Congenital urinary tract abnormalities;
Trial design
Treatments tested in this trial
- Not listed
Trial groups
270 Participants
are grouped into 2 trial groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov