Impact of Moderate Preterm Birth on Vocabulary Acquisition

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-2
SponsorAssistance Publique Hopitaux De Marseille

About this trial

Children born prematurely may present a neurodevelopmental disorder with a language delay diagnosed as early as 2-3 years of age. This situation is not uncommon: each year in France, approximately 35,000 children are born between 32 and 36 weeks of amenorrhea.

In our most recent work, we have shown that moderate premature infants show an attenuated cortical response to a vowel change, suggesting a deficit in the cortical encoding of vowels. This work needs to be continued in order to better understand syllable encoding and identify the neuroplasticity mechanisms underlying early speech encoding.

The identification of markers to predict language development is essential for the screening of these children at risk of language delay. These children could thus benefit from early adapted care even before the appearance of language deficits.

Eligibility criteria

Qualifiers

Infants born prematurely (32-36 weeks gestational age, GA) or at term (40-2 weeks gestational age, GA)

Birth weight appropriate to gestational age determined by WHO growth charts (weight, height, head circumference)

Normal clinical examination at inclusion.

Written informed consent obtained from both parents (or single parent if single parent)

Disqualifiers

Neonatal distress (Apgar score < 7)

Hypoxic and ischemic encephalopathy

Perinatal acidosis

Intrauterine growth retardation

Trial design

Treatments tested in this trial

  • Electroencephalography

Treatment groups

160 Participants
are divided into 1 treatment group