Impact of New Hormone Replacement Therapy After Menopause on Heart Health in Women

ConditionsHormone Replacement Therapy Cardiovascular Diseases Hormone Replacement Therapy, Post-Menopausal Menopause

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexFemale

Age45-75

SponsorHeinrich-Heine University, Duesseldorf

About this trial

This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women. Menopause-related estrogen deficiency leads to metabolic and vascular changes that increase atherosclerosis and cardiovascular events. This study hypothesizes that new HRT forms may reduce cardiovascular risk in high-risk women."

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 45-75 years

Score 2 > 5%

Or existing coronary heart disease

Or cAVK

Disqualifiers

Age <45 years / > 75 years

Existing cancer

Language barrier, inability to provide informed consent

GFR <30 ml/min or dialysis

Trial population

Study Population: Peri and postmenopausal women with cardiovascular disease or high risk for CVD with and without hormon replacement therapy

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

2,725 Participants

are grouped into 2 trial groups

Group A: Post menopausal women with hormone replacement therapy

Group B: Post menopausal women without hormone replacement therapy (Control)

Trial outcomes

Primary outcomes

MACCE

defined as death, cardiovascular death, myocardial infarction, stroke, Transient Ischemic Attack, revascularization

Time frame

10 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Heinrich-Heine University, Duesseldorf

Lead sponsor

Source ClinicalTrials.gov

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