• Evaluation of the effect of PTMC on LAA function by TEE at least one month after the procedure and its effectiveness in prevention of thrombi formation and cerebrovascular complications.
• Patient eligible for PTMC as anatomical characteristics àpatient with sever MS (area 1.5cm2, echocardiographic score (Wilkins score ≤ 8, Cormier score 1 and 2 …), contraindication or high risk to surgical MVR.
Patient with mitral regurgitation more than grade II .
Patient not eligible to PTMC.
Patient with severe heart failure (NHYA class IV) .
Patient with previous Cerebrovascular accident .