This study aim to evaluate the effects of protein supplements and resistance training on body composition, functional parameters, metabolic adaptation, and nitrogen balance in adults (aged ≥45 years) with overweight/obesity receiving weekly Incretin-Based obesity management medication treatment for 6 months.
A parallel design, open-label, multicenter randomized controlled trial will be conducted among 240 patients (aged ≥45 years) initiating Incretin-Based obesity management medication. Participants will be recruited through obesity clinics at the Tel-Aviv Sourasky Medical Center and the Tel-Aviv Assuta Medical Center, obesity clinics of HMOs, and social media groups. They will be randomly assigned to one of two groups in a 1:1 ratio: protein supplements ('Easy Whey' 25 gr protein/day) plus weekly resistance training and no intervention. Data will be collected at baseline, 3, and 6 months, including demographics, medical status, body composition, functional parameters, resting metabolic rate, nitrogen balance, and physical activity performance.
All participants will be advised to follow an exercise regime, a reduced-calorie diet based on the principle of the Mediterranean eating pattern and be encouraged to follow a regular meeting schedule with a registered dietitian.
Adults aged ≥45 years.
Overweight or obese (BMI ≥30, or BMI ≥27 with at least one obesity-related comorbidity).
Eligible to receive incretin-based weight loss medications (e.g. Wegovy or Mounjaro).
Able to read and speak Hebrew fluently.
Medical contraindications for incretin-based weight-loss medications.
Current treatment with insulin or sulfonylurea medications.
Inflammatory bowel disease.
Active or unstable psychiatric disorders or cognitive impairment.
Assuta Medical Center
Lead sponsor
Tel-Aviv Sourasky Medical Center
Collaborator
Ariel University
Collaborator