Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa (SIAP)
ConditionSkin Immunity
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-45
SponsorInstitut Pasteur
About this trial
Sex hormones are major regulators of skin immunity. Pregnancy represents a unique physiological state of profound hormonal remodeling. In late pregnancy, maternal levels of estrogens, progesterone, and other hormones increase dramatically, offering an unparalleled model to study the impact of sex hormones on skin immunity. Hidradenitis suppurativa (HS) provides a clinically relevant model to examine how sex hormones modulate skin inflammation.
Eligibility criteria
Qualifiers
Subject>18 years and <45 years,
Written informed consent of the subject,
Subject affiliated to the Assurance Maladie (French Health System) except Aide Médicale d'Etat (French State Medical Aid),
Subject agrees that genomic analyses may be carried out on the samples
Disqualifiers
Subject immunocompromised,
Subject under legal protection (guardianship or curatorship),
Subject is unable to provide informed consent and to comply with the study requirements due to geographical, social, or psychiatric reasons,
Subject in other research whose procedures may influence the immune system,
Trial design
Treatments tested in this trial
- Blood sample, skin microbiota and biopsy
Treatment groups
240 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Locations
Sponsors and collaborators
Source ClinicalTrials.gov