Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults

ConditionHealthy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorPurdue University

About this trial

The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota. The soluble fiber in cereal by-products, arabinoxylan (AX), is known to be beneficial for generally promoting gut health. However, it is unclear whether consuming rice bran (RB), the source of AX, is equally helpful or better than consuming the extracted form of AX. This study aims to reveal the potential benefit of insoluble cereal bran fiber ingredients by comparing the effect of soluble arabinoxylan fiber alone and the mostly insoluble rice bran fiber, containing arabinoxylan, on intestinal health and gut microbiota. A placebo (maltodextrin) will be used as a control, with no significant changes expected in this group for the evaluated outcomes.

Participants will:

* Consume two different fiber supplements (soluble arabinoxylan or stabilized rice bran) as well as a placebo (maltodextrin) for 3 weeks each, separated by a 2-week washout period. * Provide blood and stool samples at six different time points. * Complete a food and gastrointestinal symptom diary during the intervention periods.

Eligibility criteria

Qualifiers

Men or women.

Aged between 18-45 years.

Body mass index between 18.5 and 25 kg/m².

Able to read/speak English.

Disqualifiers

Gastrointestinal disorders (inflammatory bowel disease, irritable bowel syndrome, gluten sensitivity/intolerance, etc.).

Those who took antibiotics 3 months before the study.

Individuals taking regular medication or supplements that might affect the gut microbiota.

Individuals undertaking weight-loss diets.

Trial design

Treatments tested in this trial

  • Soluble Arabinoxylan
  • Rice Bran
  • Maltodextrin (Placebo)

Treatment groups

25 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Purdue University

Lead sponsor

Rural Development Administration (RDA) of the Republic of Korea

Collaborator