The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS). It sought to elucidate the complex relationships among structural abnormalities, microenvironmental changes, and inflammatory factors contributing to olfactory dysfunction through a multidimensional assessment encompassing imaging, aerodynamics, biomarker , and histopathology analysis.
Diagnosed with CRS based on the diagnostic criteria of the EPOS guideline.
Provision of signed and dated informed consent form.
Patients with CRS admitted to the hospital awaiting endoscopic sinus surgery.
Healthy controls undergoing surgery for the deviated septum.
Those who have taken oral glucocorticoids, antibiotics, anti-leukotrienes, and antihistamines within four weeks.
Patients who have had prior sinus surgery.
Patients with fungal sinusitis, inverted papilloma, or other nasal diseases.
Patients with a diagnosis of immune suppression or suspicion of malignancy that may be affecting the nose/paranasal sinuses.