This study examines whether there are differences in brain health or well-being in patients receiving TKI therapy for leukemia compared to individuals who do not receive TKI therapy.
TKI RECIPIENTS: Participants must have a diagnosis of CML or CLL
TKI RECIPIENTS: Participants must be scheduled to receive their first dose of TKI therapy for CML or CLL within 30 days or have received their first dose of TKI therapy for CML or CLL within the previous 30 days
TKI RECIPIENTS: Participants must be ≥ 18 years of age
TKI RECIPIENTS: Participants must be able to speak and read English
Participants must have no history of metastatic cancer, primary brain tumor, or brain irradiation
Participants must have no history of TKI therapy
Participants must have no history of cytotoxic chemotherapy, immune checkpoint inhibitor therapy, hormonal therapy, biologic therapy, radiotherapy within the past 5 years. However, permitted treatments include prior use of hydroxyurea for the treatment of CML or CLL as well as treatment with obinutuzumab or rituximab concurrent with TKI therapy for CLL
Participants must have no history of stroke within the past year and no remaining cognitive symptoms from any stroke prior to the past year
University of Rochester NCORP Research Base
Lead sponsor
National Cancer Institute (NCI)
Collaborator