This study is a validation study to evaluate efficacy of two neuroplasticity-based, computerized cognitive training programs to improve neurological and neuropsychological health in older adults with mild cognitive impairment (MCI).
Potential participant must be 65 years or older at the time of study screening.
Total score between 18-26 inclusive on the Montreal Cognitive Assessment (MoCA)
Cognitive concern by participant, informant, or clinician and evidence of preserved functional abilities as defined as a Clinical Dementia Rating (CDR) of 0.5 with a memory score of 0.5 or 1.
Potential participant must have a study partner/informant defined as any acquaintance (e.g., family member, friend, neighbor, clinician) who has regular (at least monthly) interactions (in person or remote) with the participant.
Potential participant has an existing diagnosis of major neurocognitive disorder at screening (DSM-IV).
Potential participant who answered 'yes' to question 5 (Active Suicidal Ideation with Specific Plan and Intent) on the C-SSRS or 'yes' to any of the suicide-related behaviors (actual attempt, interrupted attempt, aborted attempt, preparatory act or behavior) on the C-SSRS "Suicidal Behavior" if the ideation or behavior occurred within 2 months from Participant's date of consent (as recommended by the FDA for treatment trials.)
Potential participant scores >10 on the Geriatric Depression Scale - Short Form (GDS-SF).
Potential participant has previously completed 10 or more hours of the computerized cognitive intervention program manufactured by Posit Science.
Posit Science Corporation
Lead sponsor
McGill University
Collaborator